Blood Pressure Monitor (non-Invasive): NIBP
The Columbus Instruments Non- Invasive Blood Pressure (NIBP) Monitor can monitor systolic, diastolic, mean blood pressure, as well as heart rate with 7% accuracy in one to eight rats or mice. The NIBP consistently tracks the changes of systolic, diastolic, and mean blood pressure measured non-invasively and utilizes two separate cuffs. The first, positioned closely to the tail base, is used for arterial occlusion and the second, positioned down from the first cuff, is used to sense arterial pulsation. The user can schedule timing of measurements for each animal. It takes 16 seconds to complete the blood pressure measurement cycle for an animal. Subsequent measurements can be set 30 seconds apart.
The NIBP is fully automatic and results are presented on the screen and can be printed and/or saved to a file as the numerical values pressure in mmHg, as well as graphical pictures of the signal from the pulsation sensor and a graph of ascending and descending pressure in the occlusion sensor. After completion of the measurement, the user has the option to review the results by displaying signals from both cuffs and make a decision to accept or reject the measurement.
For rats and mice.
Fully automated or user interactive.
Monitors up to eight animals.
Animal's tail is pre warmed rather than heating the animal's body.
Operating Mode: Manual and automatic (timed and scheduled)
Systolic blood pressure
Diastolic blood pressure
Mean blood pressure
Range of Measurement:
Blood Pressure: 20 - 300 +/-1 mmHg
Heart Rate: 1 - 900 bpm
Pulse Detection Method: Pressured cuff, palpation
Occluding Cuff: 0 - 300 mmHg
Sensing Cuff: 0 - 100 mmHg
Resolution: 12 bits
Sampling Interval: 4 Ms
Connection with computer:
Port: RS-232 serial port
Power Requirements: 120/240 volts AC, 40 watts
Physical Dimensions: 11.5"W x 7.5"H x 13"D
Weight: 12 pounds
Cardiac Output Computer: Cardiomax III
The Cardiomax-III Thermodilution Cardiac Output Computer doubles as a physiological data acquisition system. The new thermodilution cardiac computer interfaces directly to a Pentium desktop or laptop computer via a very fast RS-232 link. It is intended to be used on a variety of lab animals from mice to horses. In addition to measuring cardiac output and associated parameters (SV, HR), the Cardiomax-III can be used to measure, display, and log ECG (EKG) with its own low level amplifier and two (2) blood pressures (DP, MP, SP, dp/dt). Storage of all parameter data is provided in c*.CSV format for easy import into a variety of analysis programs. The thermo-dilution curve image can also be saved. The Cardiomax-III can use a variety of thermistor catheters as well as Columbus Instruments thermocouple microprobes. The Cardiomax-IIIs special design makes it resistant to external radio signal interference and its small size (35.5 x 29 x 10 cm) makes it very convenient in a crowded laboratory environment.
(All isolated inputs have over 1500v of low leakage isolation to the chassis and computer connections.)
Type: "T" thermocouple or 14k - 7k ohm thermistor
Range: 0 to 50 degrees C.
Type: "T" thermocouple or 14k - 7k ohm thermistor
Range: 0 to 50Â°C
Three lead: LA, RA, RL
Range: 50uV to 2mV peak to peak
Blood Pressure Inputs (2) (-100 to + 300 mmHg range)
Resolution: 1 mmHg,
Accuracy: +/-0.5% full scale, +/-1mmHg
Transducer sensitivity: 5 uV/V/mmHg
Transducer nominal impedance: 300 ohm
Transducer Excitation: 4 volts
High Level ECG Input:
Two ranges: +/-0.25 volt, +/-1.25volt
Foot switch input for starting a C.O. measurement cycle remotely
Injector trigger output for automated C.O. injection
Computer RS-232 serial port connection: 19200 baud
120VAC, 60Hz; 240VAC, 50Hz (Factory Selected)
Fuse: 1/2 ampere, type MDA
Size: 14" x 11.5" x 4" (35.5 x 29 x 10 cm)
Weight: 6 lbs. (2.72 kg)
Pressure Transducer (Invasive) - SS13L
The SS13L is used to measure direct arterial or venous blood pressure in animals, or to record the pressure changes within an in-vitro circuit such as a Langendorff heart preparation. Connect to tubing via the standard rotating Luer Lok tube fittings. The cable terminates in a connector designed to interface with the BSL System MP3X unit. The transducer comes with a Velcro strap for easy mounting. The transducer is supplied non-sterile but can be sterilized using ethylene oxide (ETO) gas. Replacement transducers (RX104A) can be purchased without the cable, making this a very economical solution.
Operational pressure: -50 mmHg to +300 mmHg
Overpressure: -500 mmHg to + 4000 mmHg
Sensitivity: 25 uV/mmHg (at 5 VDC excitation)
Accuracy: ± 1.5% of reading or ± 1.0 mmHg (whichever is greater)
Operating temperature: 10° C to 40° C
Storage temperature: -30° C to +60° C
Volume displacement: 0.04 mm per 100 mmHg
Leakage current: 10 uA RMS @ 115 VAC 50 Hz
Dynamic response: 100 Hz
Unbalance: 50 mmHg max
Connection Ports: male Luer and female Luer (sensors shipped prior to summer 2010 were male Luer on both sides)
Eight-hour drift: 1 mmHg after 5-minute warm-up
Isolation: <= 5 uA leakage at 120 VAC/60 Hz
Defibrillation: Withstands 5 charges of 400 joules in 5 minutes across a load
Combined effects of sensitivity, linearity and hysteresis: 1 mmHg (nominal)
Transducer cable: 30 cm
Interface cable: 3 meters
Transducer dimensions: 67 mm long X 25 mm wide
Weight: 11.5 grams
Neddle Electrode for ECG (Invasive) - EL452, EL451
Animal ECG (Invasive): Use needle electrodes in animal subjects and tissue preparations for stimulation or recording.
These 28-gauge stainless steel needle electrodes are equipped with a flexible lead terminating in one standard Touchproof connector. This needle electrode is fully insulated with a clear Teflon overcoat, except for the conductive needle tip. The coating prevents the needle from making contact with the subject except at the very tip of the needle, which is exposed. For applications that require better contact between the electrode and the subject to record a good signal, abrade the needle to remove the Teflon coating.
- For stimulation, use a pair of EL450 or EL452 electrodes.
- For general-purpose recording (e.g. ECG), use a pair of EL450 or EL452 electrodes, plus one EL452 ground electrode.
- When recording from a single site (e.g. studies of individual muscle fibers), use one EL451 electrode plus one EL452 ground electrode.
Non Invasive Blood Pressure Amplifier - NIBP100D
Non Invasive Blood Pressure Amplifier: The NIBP100D non-invasive blood pressure system provides a continuous, beat-to-beat, blood pressure signal recorded from the fingers of a subject. The non-invasive blood pressure (NIBP) monitoring system uses a double finger cuff that is comfortable for the subject to wear and easy to place on the hand. The system includes three cuff sizes to accommodate small children through large adults. The system outputs a continuous blood pressure waveform that is similar to a direct arterial pressure waveform. The monitor displays values for systolic, diastolic, mean blood pressure, and heart rate.
- Accurate non-invasive blood pressure values
- Easy to use...set up & calibrate in just minutes!
- Comfortable for subjects in short or long term studies
- Real-time, continuous, non-invasive blood pressure
- Module display language options: EN, DE, FR, ES, IT
Double-Cuff Finger Sensors – one each size
L 24 - 28 mm dark red, M 18 - 24 mm Dark blue, S 10 - 18 mm Light blue
Finger cuff sensors are a consumable item and typically last ~12 months based on 3-4 hours/week.
Blood Pressure Cuffs — one each size, latex-free
Child (12 – 19 cm), Small Adult (17 – 25 cm), Adult (23 – 33 cm),
Large Adult (31 – 40 cm)
Dimensions 280 x 270 x 250 mm (11 x 10.6 x 9.8 in.)
Weight 7.5 Kg (16.6 lbs.) including components and accessories necessary for operability of device
Battery Sealed lead gel, operating time = 2 hrs. (fully charged battery, normal conditions)
Non Invasive Cardiac Output - NICO100C
Non Invasive Cardiac Output: The NICO100C Impedance Cardiography (ICG) Non-invasive Cardiac Output Module records specific parameters associated with cardiac output measurements. It incorporates a precision high frequency current source, which injects a very small (400 µA) measurement current through the thoracic volume defined by the placement of a set of current source electrodes. A separate set of monitoring electrodes measures the voltage developed across the thorax volume. Because the current is constant, the voltage measured is proportional to the impedance characteristics of the thorax.
The NICO100C simultaneously measures impedance magnitude (Zo; labelled "Z") and derivative (dZ/dt; labelled "DZ"). Zo and dZ/dt can be recorded at four different measurement frequencies, from 12.5 kHz to 100 kHz; cardiac output measurements are usually performed at a measurement frequency of 50 kHz.
Number of Channels: 2 – Magnitude (Zo) and dZ/dt
Operational Frequencies: 12.5, 25, 50, 100 kHz
Current Output: 400µA (rms)—constant sinusoidal current
Outputs: MAG of Impedance: 0-100 Ω dZ/dt of
Impedance: 2 (Ω/sec)/v Output Range: ±10 V (analog)
CMIV, referenced to… Amplifier ground: ±10 V
Mains ground: ±1500 VDC
Signal Source: Electrodes (requires 4 electrode leads)
Gain Range: MAG: 10, 5, 2, 1 Ω/V
dZ/dt: 2 (Ω/sec)/v constant (independent of MAG Gain)
LP Filter: MAG: 10 Hz, 100 Hz dZ/dt: 100 Hz
HP Filter: MAG: DC, 0.05 Hz dZ/dt: DC coupled
Sensitivity: MAG: 0.0015 Ω rms @ 10 Hz bandwidth dZ/dt: 0.002 (Ω/sec) rms @ 10 Hz bandwidth
Weight: 370 g Dimensions: 4 cm (wide) x 11 cm (deep) x 19 cm (high)
Blood Pressure Cuff Transducer - SS19L
Blood Pressure Cuff Transducer: The SS19L non-invasive blood pressure cuff comes complete with adjustable cuff (circumference range 25.4 - 40.6 cm), pump bulb, pressure gauge, and pressure transducer. The pressure transducer is attached to the cuff and connects directly to the MP30 unit.
The transducer is designed to work with our SS17L Physiological Sounds Microphone for the evaluation of systolic and diastolic blood pressure. When the microphone is used to record the Korotkoff sounds it is easy to obtain very accurate and repeatable results, usually within 10% of those determined by direct measurement.
Pressure range: 20 mmHg to 300 mmHg
Manometer accuracy: ±3 mmHg
Output: 5 µV/mmHg (normalized to 1 V excitation)
Cuff circumference range: 25.4 cm to 40.6 cm (as shipped with RX120 d; cuff is switchable)
Cuff Dimensions: 14.5 cm (wide) x 54 cm (long)
Weight: 350 grams Cable Length: 3 meters, shielded
3 Lead ECG - SS2LB (Wired)
3 Lead ECG: This fully-shielded cable assembly permits high resolution recording of biopotentials using our EL500 series disposable electrodes. The 2 meter adapter is terminated with standard pinch connectors to interface with EL500 series snap electrodes. The SS2LB interfaces with Biopac Student Lab data acquisition units (MP3X or MP45) and the MP36R research unit.
Cable Length: 2 meters
Connector Type: 9 Pin DIN
Multi Lead ECG - SS29L (Wired)
Multi Lead ECG: The SS29L Multi-Lead ECG Cable permits high resolution electrocardiogram recordings. The lead set will allow you to simultaneously record Leads I, II, III, aVR, aVL, aVF, plus one precordial chest lead. A 12-Lead ECG recording can be obtained by alternating the chest lead electrode from position V1 through V6. The cable is terminated in three smart sensors which connect to three MP3X analog input channels.
Input Cable Length: 2 meters
Electrode Lead Length: 1 meter
Internal connection: Built-in Wilson terminal
Electrode interface: Connects to standard snap-connector disposable electrodes (EL503)
The latest generation of BioNomadix Transmitters can operate with the BioNomadix Logger or a matched BioNomadix Receiver to noninvasively record full signal bandwidth physiology data. BioNomadix Transmitters are typically dual-channel devices, offering either two of the same biopotential or transducer signal or a combination of signals. Transmitters can easily be synced with a Logger for data logging and later download to AcqKnowledge or to a matched Receiver and MP150 System for live data recording in AcqKnowledge. AcqKnowledge can combine data from multiple transmitters into one graph file. Multiple transmitters can be used with a BioNomadix System for multi-subject or multi-parameter research studies.
BioNomadix signal types include: ECG, EEG, EMG, EOG, EGG, EDA, Pulse, Respiration, Temperature, Impedance Cardiography (NICO), Strike Force (Heel-Toe), Clench Force (Dynamometry), Goniometry, Torsiometry, and Accelerometry.
Nevrokard HRV Analysis Software
Nevrokard HRV Analysis Software
Nevrokard – flexible, versatile, professional software tools for serious research of the autonomic nervous system & sleep apnea in humans.
Nevrokard small animals - SA - programs – specialized tools for study of Heart Rate Variabiliy (HRV), Blood Pressure Variability (BPV) and Baroreflex Sensitivity (BRS) in mice, rats and other small animals.
Our analytical software is compatible with most data formats and with files acquired by the following major data acquisition systems:
Heart Sounds (SS30L)
The SS30L was developed to teach students the standard procedure for listening to heart sounds and Korotkoff sounds with a normal stethoscope and at the same time record sound data. A microphone in the stethoscope simultaneously records the sound the student is hearing, and the BSL software will display the soundwave during and after recording. If ECG is also recorded, students can correlate the timing of the heart sounds with the ECG.
Note: For research applications the SS17L Physiological Sounds Microphone may be a more versatile option.
Microphone Bandwidth: 20-100 Hz (does not impact acoustical bandwidth, used for data viewing) Stethoscope Length:
From Y to acoustic sensor point: 57 cm
From Y to ears: 21 cm
Microphone Cable length: 3 meters