Blood Pressure Monitor (non-Invasive): NIBP

The Columbus Instruments Non- Invasive Blood Pressure (NIBP) Monitor can monitor systolic, diastolic, mean blood pressure, as well as heart rate with 7% accuracy in one to eight rats or mice. The NIBP consistently tracks the changes of systolic, diastolic, and mean blood pressure measured non-invasively and utilizes two separate cuffs. The first, positioned closely to the tail base, is used for arterial occlusion and the second, positioned down from the first cuff, is used to sense arterial pulsation. The user can schedule timing of measurements for each animal. It takes 16 seconds to complete the blood pressure measurement cycle for an animal. Subsequent measurements can be set 30 seconds apart.
The NIBP is fully automatic and results are presented on the screen and can be printed and/or saved to a file as the numerical values pressure in mmHg, as well as graphical pictures of the signal from the pulsation sensor and a graph of ascending and descending pressure in the occlusion sensor. After completion of the measurement, the user has the option to review the results by displaying signals from both cuffs and make a decision to accept or reject the measurement.


For rats and mice.
Fully automated or user interactive.
Monitors up to eight animals.
Animal's tail is pre warmed rather than heating the animal's body.
Operating Mode: Manual and automatic (timed and scheduled)
Non-Invasive Measurements:
Systolic blood pressure
Diastolic blood pressure
Mean blood pressure
Heart rate
Range of Measurement:
Blood Pressure: 20 - 300 +/-1 mmHg
Heart Rate: 1 - 900 bpm
Pulse Detection Method: Pressured cuff, palpation
Inflation Pressure:
Occluding Cuff: 0 - 300 mmHg
Sensing Cuff: 0 - 100 mmHg
Data Acquisition:
Resolution: 12 bits
Sampling Interval: 4 Ms
Connection with computer:
Port: RS-232 serial port
Format: 19200,N,8
Power Requirements: 120/240 volts AC, 40 watts
Physical Dimensions: 11.5"W x 7.5"H x 13"D
Weight: 12 pounds

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Cardiac Output Computer: Cardiomax III

The Cardiomax-III Thermodilution Cardiac Output Computer doubles as a physiological data acquisition system. The new thermodilution cardiac computer interfaces directly to a Pentium desktop or laptop computer via a very fast RS-232 link. It is intended to be used on a variety of lab animals from mice to horses. In addition to measuring cardiac output and associated parameters (SV, HR), the Cardiomax-III can be used to measure, display, and log ECG (EKG) with its own low level amplifier and two (2) blood pressures (DP, MP, SP, dp/dt). Storage of all parameter data is provided in c*.CSV format for easy import into a variety of analysis programs. The thermo-dilution curve image can also be saved. The Cardiomax-III can use a variety of thermistor catheters as well as Columbus Instruments thermocouple microprobes. The Cardiomax-IIIs special design makes it resistant to external radio signal interference and its small size (35.5 x 29 x 10 cm) makes it very convenient in a crowded laboratory environment.


Isolated inputs
(All isolated inputs have over 1500v of low leakage isolation to the chassis and computer connections.)

Catheter Input
Type: "T" thermocouple or 14k - 7k ohm thermistor
Range: 0 to 50 degrees C.
Injected Input
Type: "T" thermocouple or 14k - 7k ohm thermistor
Range: 0 to 50°C
ECG Input
Three lead: LA, RA, RL
Range: 50uV to 2mV peak to peak
Blood Pressure Inputs (2) (-100 to + 300 mmHg range)
Resolution: 1 mmHg,
Accuracy: +/-0.5% full scale, +/-1mmHg
Transducer sensitivity: 5 uV/V/mmHg
Transducer nominal impedance: 300 ohm
Transducer Excitation: 4 volts
Non-isolated connections
High Level ECG Input:
Two ranges: +/-0.25 volt, +/-1.25volt
Foot switch input for starting a C.O. measurement cycle remotely
Injector trigger output for automated C.O. injection
Computer RS-232 serial port connection: 19200 baud
Power requirements
12 watts
120VAC, 60Hz; 240VAC, 50Hz (Factory Selected)
Fuse: 1/2 ampere, type MDA
Size: 14" x 11.5" x 4" (35.5 x 29 x 10 cm)
Weight: 6 lbs. (2.72 kg)

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Pressure Transducer (Invasive) - SS13L

The SS13L is used to measure direct arterial or venous blood pressure in animals, or to record the pressure changes within an in-vitro circuit such as a Langendorff heart preparation. Connect to tubing via the standard rotating Luer Lok tube fittings. The cable terminates in a connector designed to interface with the BSL System MP3X unit. The transducer comes with a Velcro strap for easy mounting. The transducer is supplied non-sterile but can be sterilized using ethylene oxide (ETO) gas. Replacement transducers (RX104A) can be purchased without the cable, making this a very economical solution.


Operational pressure: -50 mmHg to +300 mmHg

Overpressure: -500 mmHg to + 4000 mmHg

Sensitivity: 25 uV/mmHg (at 5 VDC excitation)

Accuracy: ± 1.5% of reading or ± 1.0 mmHg (whichever is greater)

Operating temperature: 10° C to 40° C

Storage temperature: -30° C to +60° C

Volume displacement: 0.04 mm per 100 mmHg

Leakage current: 10 uA RMS @ 115 VAC 50 Hz

Dynamic response: 100 Hz

Unbalance: 50 mmHg max

Connection Ports: male Luer and female Luer (sensors shipped prior to summer 2010 were male   Luer on both sides)

Eight-hour drift: 1 mmHg after 5-minute warm-up

Isolation: <= 5 uA leakage at 120 VAC/60 Hz

Defibrillation: Withstands 5 charges of 400 joules in 5 minutes across a load

Combined effects of sensitivity, linearity and hysteresis: 1 mmHg (nominal)

Transducer cable: 30 cm

Interface cable: 3 meters

Transducer dimensions: 67 mm long X 25 mm wide

Weight: 11.5 grams

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Neddle Electrode for ECG (Invasive) - EL452, EL451

Animal ECG (Invasive): Use needle electrodes in animal subjects and tissue preparations for stimulation or recording.

These 28-gauge stainless steel needle electrodes are equipped with a flexible lead terminating in one standard Touchproof connector. This needle electrode is fully insulated with a clear Teflon overcoat, except for the conductive needle tip. The coating prevents the needle from making contact with the subject except at the very tip of the needle, which is exposed. For applications that require better contact between the electrode and the subject to record a good signal, abrade the needle to remove the Teflon coating.

  • For stimulation, use a pair of EL450 or EL452 electrodes.
  • For general-purpose recording (e.g. ECG), use a pair of EL450 or EL452 electrodes, plus one EL452 ground electrode.
  • When recording from a single site (e.g. studies of individual muscle fibers), use one EL451 electrode plus one EL452 ground electrode.

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Non Invasive Blood Pressure Amplifier - NIBP100D

Non Invasive Blood Pressure Amplifier: The NIBP100D non-invasive blood pressure system provides a continuous, beat-to-beat, blood pressure signal recorded from the fingers of a subject. The non-invasive blood pressure (NIBP) monitoring system uses a double finger cuff that is comfortable for the subject to wear and easy to place on the hand. The system includes three cuff sizes to accommodate small children through large adults. The system outputs a continuous blood pressure waveform that is similar to a direct arterial pressure waveform. The monitor displays values for systolic, diastolic, mean blood pressure, and heart rate.

  • Accurate non-invasive blood pressure values
  • Easy to use...set up & calibrate in just minutes!
  • Comfortable for subjects in short or long term studies
  • Real-time, continuous, non-invasive blood pressure
  • Module display language options: EN, DE, FR, ES, IT 


Double-Cuff Finger Sensors – one each size

L 24 - 28 mm dark red, M 18 - 24 mm Dark blue, S 10 - 18 mm Light blue

Finger cuff sensors are a consumable item and typically last ~12 months based on 3-4 hours/week.

Blood Pressure Cuffs — one each size, latex-free

Child (12 – 19 cm), Small Adult (17 – 25 cm), Adult (23 – 33 cm),

Large Adult (31 – 40 cm)

NIBP100D Monitor

Dimensions 280 x 270 x 250 mm (11 x 10.6 x 9.8 in.)

Weight 7.5 Kg (16.6 lbs.) including components and accessories necessary for operability of device

Battery Sealed lead gel, operating time = 2 hrs. (fully charged battery, normal conditions)

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Non Invasive Cardiac Output - NICO100C

Non Invasive Cardiac Output: The NICO100C Impedance Cardiography (ICG) Non-invasive Cardiac Output Module records specific parameters associated with cardiac output measurements. It incorporates a precision high frequency current source, which injects a very small (400 µA) measurement current through the thoracic volume defined by the placement of a set of current source electrodes. A separate set of monitoring electrodes measures the voltage developed across the thorax volume. Because the current is constant, the voltage measured is proportional to the impedance characteristics of the thorax.

The NICO100C simultaneously measures impedance magnitude (Zo; labelled "Z") and derivative (dZ/dt; labelled "DZ"). Zo and dZ/dt can be recorded at four different measurement frequencies, from 12.5 kHz to 100 kHz; cardiac output measurements are usually performed at a measurement frequency of 50 kHz.


Number of Channels: 2 – Magnitude (Zo) and dZ/dt 

Operational Frequencies: 12.5, 25, 50, 100 kHz 

Current Output: 400µA (rms)—constant sinusoidal current 

Outputs: MAG of Impedance: 0-100 Ω dZ/dt of

Impedance: 2 (Ω/sec)/v Output Range: ±10 V (analog) 

CMIV, referenced to… Amplifier ground: ±10 V

Mains ground: ±1500 VDC

Signal Source: Electrodes (requires 4 electrode leads) 

Gain Range: MAG: 10, 5, 2, 1 Ω/V

dZ/dt: 2 (Ω/sec)/v constant (independent of MAG Gain) 

LP Filter: MAG: 10 Hz, 100 Hz             dZ/dt: 100 Hz

HP Filter: MAG: DC, 0.05 Hz                dZ/dt: DC coupled

Sensitivity: MAG: 0.0015 Ω rms @ 10 Hz bandwidth dZ/dt: 0.002 (Ω/sec) rms @ 10 Hz bandwidth

Weight: 370 g  Dimensions: 4 cm (wide) x 11 cm (deep) x 19 cm (high)   

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Blood Pressure Cuff Transducer - SS19L

Blood Pressure Cuff Transducer: The SS19L non-invasive blood pressure cuff comes complete with adjustable cuff (circumference range 25.4 - 40.6 cm), pump bulb, pressure gauge, and pressure transducer. The pressure transducer is attached to the cuff and connects directly to the MP30 unit.

The transducer is designed to work with our SS17L Physiological Sounds Microphone for the evaluation of systolic and diastolic blood pressure. When the microphone is used to record the Korotkoff sounds it is easy to obtain very accurate and repeatable results, usually within 10% of those determined by direct measurement.


Pressure range: 20 mmHg to 300 mmHg

Manometer accuracy: ±3 mmHg

Output: 5 µV/mmHg (normalized to 1 V excitation)

Cuff circumference range: 25.4 cm to 40.6 cm (as shipped with RX120 d; cuff is switchable)

Cuff Dimensions: 14.5 cm (wide) x 54 cm (long)

Weight: 350 grams Cable Length: 3 meters, shielded

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3 Lead ECG - SS2LB (Wired)

3 Lead ECG: This fully-shielded cable assembly permits high resolution recording of biopotentials using our EL500 series disposable electrodes. The 2 meter adapter is terminated with standard pinch connectors to interface with EL500 series snap electrodes. The SS2LB interfaces with Biopac Student Lab data acquisition units (MP3X or MP45) and the MP36R research unit.


Cable Length: 2 meters

Connector Type: 9 Pin DIN

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Multi Lead ECG - SS29L (Wired)

Multi Lead ECG: The SS29L Multi-Lead ECG Cable permits high resolution electrocardiogram recordings. The lead set will allow you to simultaneously record Leads I, II, III, aVR, aVL, aVF, plus one precordial chest lead. A 12-Lead ECG recording can be obtained by alternating the chest lead electrode from position V1 through V6. The cable is terminated in three smart sensors which connect to three MP3X analog input channels.


Input Cable Length:  2 meters

Electrode Lead Length:  1 meter

Internal connection:  Built-in Wilson terminal

Electrode interface:  Connects to standard snap-connector disposable electrodes (EL503)

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Wireless ECG

The latest generation of BioNomadix Transmitters can operate with the BioNomadix Logger or a matched BioNomadix Receiver to noninvasively record full signal bandwidth physiology data. BioNomadix Transmitters are typically dual-channel devices, offering either two of the same biopotential or transducer signal or a combination of signals. Transmitters can easily be synced with a Logger for data logging and later download to AcqKnowledge or to a matched Receiver and MP150 System for live data recording in AcqKnowledge. AcqKnowledge can combine data from multiple transmitters into one graph file. Multiple transmitters can be used with a BioNomadix System for multi-subject or multi-parameter research studies.

BioNomadix signal types include: ECG, EEG, EMG, EOG, EGG, EDA, Pulse, Respiration, Temperature, Impedance Cardiography (NICO), Strike Force (Heel-Toe), Clench Force (Dynamometry), Goniometry, Torsiometry, and Accelerometry.

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Nevrokard HRV Analysis Software

Nevrokard HRV Analysis Software

 Nevrokard – flexible, versatile, professional software tools for serious research of the autonomic nervous system & sleep apnea in humans. 

Nevrokard small animals - SA - programs – specialized tools for study of Heart Rate Variabiliy (HRV), Blood Pressure Variability (BPV) and Baroreflex Sensitivity (BRS) in mice, rats and other small animals.



THE software for advanced Heart Rate Variability Analysis, suitable also for fetal Heart Rate Variability. Includes both a manual AND an automatic Data Editor, as well as the Export Results utility! Small Animal advanced Heart Rate Variability Analysis SA-aHRV software is available as well!


Long-term advanced Heart Rate Variability software for segmented analysis of ECG recordings, with numeric and 3D graphic output of results. Compatible with the same file types as Nevrokard aHRV. Small Animal advanced Heart Rate Variability Analysis SA-LTaHRV software is available as well!


Software for direct comparison of Heart Rate Variability parameters in the time and frequency domains during periods of wakefulness and sleep, thus enabling the doctor to quantify the suspicion of obstructive sleep apnea in the patient.


Software for Blood Pressure Variability Analysis - compatible with Finapres®, Finometer®, Portapres®, Colin® and BIOPAC® monitors. Small Animal Blood Pressure Variability Analysis SA-BPV software is available as well!


Software for Baroreflex Sensitivity Analysis  - compatible with Finapres®, Finometer®, Portapres®, Colin® and BIOPAC® monitors. Small Animal Baroreflex Sensitivity Analysis SA-BRS software is available as well!


Software for analysis of all the Cardiovascular Parameters recorded by non-invasive continuous cardiac output monitor Finometer® (Finapres®) or Niccomo® (Medis®) in both time and frequency domains.


Laser Doppler Data Analysis - software for analysis of data obtained with Laser Doppler instruments (e.g. Moor Instruments® or Perimed®) for evaluation of microvascular perfusion.

Our analytical software is compatible with most data formats and with files acquired by the following major data acquisition systems:


  Axon Instruments®  

  Forest Medical®

  Nihon Kohden®

  Bio-Impedance Technology, Inc.®



  Bio-Logic Science Instruments ®

  GE® Marquette®


  BIOPAC Systems® AcqKnowledge®



  BIOPAC® Zephyr® BioHarness®

  LiDCO® plus


  BIT Bio-Impedance Technology®


  RS Techmedic Dyna-Vision®

  BMEYE®  Nexfin®

  Medis Medizinische Messtechnik®

  SIGMA Medizin-Technik®

  Cardiac Science Burdick®

  Mega Electronics eMotion®




  Spacelabs Medical®

  CED Cambridge Electronic Design®

  Mini Mitter®


 Custo med Gmbh.

  Moor Instruments®


  DATAQ Instruments®

  Mortara H-Scribe®

  TMS International®

  Del Mar Reynolds®

  National Instruments BioBench ®


  DSI - Data Sciences International®



  Finapres Medical Systems®




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Heart Sounds (SS30L)

The SS30L was developed to teach students the standard procedure for listening to heart sounds and Korotkoff sounds with a normal stethoscope and at the same time record sound data. A microphone in the stethoscope simultaneously records the sound the student is hearing, and the BSL software will display the soundwave during and after recording. If ECG is also recorded, students can correlate the timing of the heart sounds with the ECG.

Note: For research applications the SS17L Physiological Sounds Microphone may be a more versatile option.


Microphone Bandwidth: 20-100 Hz (does not impact acoustical bandwidth, used for data viewing) Stethoscope Length: 

From Y to acoustic sensor point: 57 cm 

From Y to ears: 21 cm

Microphone Cable length: 3 meters  

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