Any-Maze Video Tracking Software

ANY-maze is a flexible video tracking system designed to automate testing in behavioural experiments. Packed with advanced features ANY-maze is one of the most comprehensive video tracking systems available today.

ANY-maze's flexible design makes it easy to set up experiments in a wide range of different apparatus - plus maze, water-maze, T-maze, activity boxes, forced swim test, etc.

Actually running tests in ANY-maze is very simple - the system can even start them automatically - and concise reports help you to see exactly where you're up to.

ANY-maze can report on more than 100 measures for individual animals or tests. It can also use over 30 statistical tests to analyse these results between groups of animals.

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Tail Suspension

The tail-suspension test is akin to the forced swim test but avoids the problems of hypothermia and stress associated with forced swimming. Animals are suspended by their tails and the amount of "immobility" is measured. Longer periods of immobility are associated with higher depressive scores and immobility can be reversed with antidepressant treatment.

Features

  • Designed specifically for use with ANY-maze
  • Suitable for use with Rats and Mice
  • Convenient, removable walls for easy cleaning

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Parallel Rod Floor Apparatus

The Parallel Rod Floor Apparatus, designed for assessing the effects of drugs, brain damage and disease, on motor coordination and fatigue, is ideal for use with knockout and transgenic mice. The Parallel Rod Floor Tests high throughput design makes it an extremely versatile and valuable screening and phenotyping tool. Adapted from the apparatus first described and developed by Drs. Kamens and Crabbe, the Parallel Rod Floor Test is a new model of ataxia in mice. The Parallel Rod Floor Test allows for the simultaneous measurement of ataxia and locomotor activity, adding variety to the battery of other tests currently available.

Features

  • Easier to use than Rota-Rod
  • Similar measurements to Rota-Rod testing
  • Uses ANY-maze software

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Light/Dark Box

The Light/Dark Box is a characteristic tool used in the assessment of anxiety. The basic measure is the animal’s preference for dark, enclosed places over bright, exposed places. Time spent in the lit (light) half of the arena, and the related exploratory behaviors, are reliable parameters for assessing anxiolytic effects that may be useful in identifying and/or screening of anxiolytic and anxiogenic agents.

Features

  • Available for rat or mouse (mouse version picture above).
  • Walls fit solidly in slotted base, but lift off for easy cleaning.
  • Grey, non-reflective base plate.
  • A fully automated version of this test, for mouse, is also available.
  • Rat version (pictured above) has two enclosures on a single base.
  • Dark side lids lift off.

Black perspex is infrared transparent allowing a suitable camera to see into both sides of the box (requires an infra-red illuminator).

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Novel Object

This Test is based on the premise that rodents will explore a novel object more than a familiar one if the animal is able to remember the familiar one. Following the training period, the rodent is removed from the environment for a delay period which can range from 5 minutes to 24 hours, depending on the type of memory being tested. After the delay, the rodent is returned to the arena, where one of the original objects has been replaced by a new, dissimilar Novel Object. The amount of time the rodent spends exploring each object provides a powerful measurement of memory integrity and attention.

Following the training period, the rodent is removed from the environment for a delay period which can range from 5 minutes to 24 hours, depending on the type of memory being tested. After the delay, the rodent is returned to the arena, where one of the original objects has been replaced by a new, dissimilar Novel Object. The amount of time the rodent spends exploring each object provides a powerful measurement of memory integrity and attention. 

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Tail Flick

The Ugo Basile Tail Flick has been designed to measure accurately the nociceptive threshold to infrared heat stimulus on the rat or mouse tail. The operator starts the stimulus: when the animal feels pain and flicks its tail, a sensor detects it, stops the timer and switches off the bulb. The reaction time of the animal is thus determined and automatically recorded.

Features

  • Direct connection to a PC
  • PC Interface to serial and USB ports via the adaptor provided
  • Operating Intensity presettable in 1 digit increments
  • Multifunction graphic display readout
  • Memory stick provided with the standard package
  • No protruding elements: flush mounted infrared window
  • Comfortable, unobstructed working surface
  • No stray radiation

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Any-maze Interface

Video tracking alone has its limitations; what do you do if you need to count the number of licks at a water bottle or determine how far an animal runs in an exercise wheel? Video-tracking alone can’t help. The answer is AMi, the ANY-maze interface, which makes all this, and much more, not just possible, but easy to achieve.

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Any Box

Stoelting’s Multi-Configuration Behavior Apparatus is a completely automated system designed to make behavioral tracking convenient and affordable without compromising features. At the heart of ANY-box is the critically acclaimed ANY-maze software, coupled to Stoelting’s ANY-maze interface (AMi) device. This combination of core components allows you to automate as many as eight ANY-boxes for simultaneous testing.

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Hot/Cold Plate

This new version of the classic instrument now works with ramping temperature (increasing or decreasing) and in a wide range of temperatures (from 2°C to 66°C). With these new features scientists can perform allodynia experiments, study receptors for cold sensitivity and run “dynamic” experiments, by changing the plate at a desired rate.

Features

  • Two Working Modes:  fixed temperature or ramping
  • Touch Screen Display
  • Operating Temperature from -5°C to 65°C in steps of 0.1°C
  • Memory Stick Provided 
  • New Software

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Conditioned Place Preference

Used in a wide variety of paradigms. Most commonly it is used in the assessment of the rewarding property of drugs (or other natural reinforces) or to identify the neuronal basis of reinforcement expression. Typically, a drug is injected, and the animal is placed in a test chamber with distinctive environmental cues. This procedure is repeated for several days.

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Porsolt

The Porsolt “Forced Swim” Test (also known as the behavioral despair test) is the most commonly used test for assessment of depression in animal models. The test is commonly used to measure the effect of antidepressant drugs on behavior. 

Features

  • Handles for convenient carrying, positioning, emptying and cleaning
  • The Porsolt Arena accommodates top and side camera placement, and is well suited for use with both Mice and Rats
  • Center drain
  • Valve for water level adjustment and initial emptying

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Incapacitance

The Incapacitance Tester offers an automatic and reproducible assessment of analgesic potency by measuring the weight distribution on the two hind paws of a small subject. The force exerted by each limb (measured in grams) is averaged over a user selectable period thus indicating any tendency for the subject to shift its weight from one side to another, hence providing a quantitative measurement of incapacitance.

Features

  • Averaging Period: 0-255 seconds
  • Accurate to 0.1g
  • RS232 Output for PC or Printer
  • Up to 255 units can be interconnected
  • Footswitch provided for hands-free operation
  • Large, high-contrast display
  • Incapacitance Meter Software (included)

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Formalin Test

The Formalin Test for nociception involves injecting a noxious substance (typically a, 3% Formalin solution) into the plantar surface of rodent's hind paw. The rodent reacts to the Formalin injection by licking and flinching the injected hind paw. The Painless instrument automates the task by determining the number of times the animal flinches over a user defined period of time (traditionally one hour).

Features

  • Ideal for Formalin Test automation
  • Measures Formalin-induced agitation responses
  • High throughput screening assessment apparatus
  • Easy to use with straight forward assembly and menu-driven software 
  • Expands to include 16 test stations
  • Converts for adult and juvenile rats and mice and other small lab animals
  • “View Wave™” data format for data analysis and validation 
  • Animal isolation cabinets minimize transfer of ultrasonic vocalizations or pheromones among subjects 
  • CE compliant
  • Independent contract lab validation
  • Tightly coupled sensor system
  • Software controlled

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Acceleration/Velocity Race Track

This runway race-track is used to assess acceleration and velocity of small animals as they run end to end. The runway measures 2.5 meters long and has an adjustable width between 2.5 and 12.5 centimeters. Walls are designed with height extensions to accommodate larger animals that may be able to jump out of the track lane. Photobeam curtains are spaced evenly at 10 centimeter intervals (24 gates total); as the subject runs end to end they break these photobeams and time is measured between each gate allowing for calculation of acceleration and velocity. System comes complete with software, cables, and all hardware.

Features

Stainless Steel Construction
Photobeam Curtains easily removable without tools
Textured rubber runway to facilitate grip and traction
Available in custom sizes

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Multi-Varimex

Multi-Varimex is unique to Columbus Instruments' line of infrared photocell-based activity monitors. Multi-Varimex allows for user placement of up to 128 infrared photo-cell emitter/detector pairs. Photocell placement may be such that many cages can be monitored by a single computerized system. The freedom to place photocells as required also allows for monitoring complex maze environments. Placement of photocells at key points in a maze provides segmentation of the monitored space that automates scoring of behavior.
Open-field monitoring can be accomplished with spatial resolutions that precisely meet the monitoring demands. Increased sensitivity can be achieved with closer beam placement. The low resolution allows concurrent monitoring of more animals, making Multi-Varimex much cost productive where a large number of cages are required.

Multi-Varimex can be equipped with software for open-field and/or maze monitoring. Columbus Instruments' Universal Maze Monitor Software (UMMS) for Multi-Varimex is a comprehensive tool for scoring maze exploration and learning. UMMS records all infrared photocell information into a file that contains identification of the photocell and the exact moment of the events.

Features

User-defined infrared photocell placement
Support for up to 128 infrared photocells
Ideal for Maze monitoring
Economical solution for cage racks
Comes complete with PC interface & software for
general activity monitoring (Activity)
Optional software available for maze monitoring (Activity, Zones, Latency, and "Null" zones)
Creates spreadsheet 'importable' data files
Emitter/Detector distances up to 36" (90cm)
120/220VAC 60/50Hz Operation
0.16" (4mm) beam diameter

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Opto - M4

The Columbus Instruments Opto M4 is our latest implementation of our popular multi-channel activity monitor that supports a variety of sensor lengths and configurations (successor to the previous generation's Opto M3). Up to 32 channels are supported providing both ambulatory and total counts for each channel. Communication is via serial RS-422 using the CI Bus protocol (MDI Software). Cabling is simplified by the use of 8 channel hubs that connect to the Opto M4 with 25 pin shielded cables. Sensor cabling uses convenient RJ-45 connectors and sensor power is supplied from the Opto M4 controller over the signal cables so no external power supplies are required. Unique to this system is the ability to re-arrange sensors to change the coverage of each cage. For example, a 20 cage X axis only system can be reconfigured to measure X and Z axes in 10 cages. Additional sensors and brackets can be purchased to expand the number of cages or coverage per cage. The Opto M4 can also be integrated with other CI Bus compatible instruments to incorporate multiple measurement parameters such as feeding mass/bouts, drinking volume, VO2 and VCO2, etc.

Features

Differentiates between Ambulatory movement vs. Total movement
Compact design
Rat Sensor Beam Spacing: 1" (2.54cm); available lengths are 8" (20.32cm), 12" (30.48cm) & 16" (40.64cm)
Mouse Sensor Beam Spacing: 0.5" (1.27cm); available lengths are 4" (10.16cm) & 8" (20.32cm)
MDI Software compatible
Beam Diameter: 0.125" (.32cm)
Beam Scan Rate: 160 Hz
Power Requirements: 50 Watts (110 VAC, 60 Hz, or 220 VAC, 50 Hz; factory selected) 

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Opto-Varimex-5

The Columbus Instruments latest Opto-Varimex-5 Auto Track System is the 5th generation of our animal activity meter designed for the Open Field Anxiety and Exploratory Tests. The Auto-Track is an advanced system using the latest technology to quantify locomotor activity and trace the animal's path for behavioral analysis. Systems can support up to 16 stations on a single PC and come complete with cages, sensors, brackets, interface, and Windows software.
The simultaneous interruption of beams along the horizontal axes (X & Y) provide coordinates that identify animal location. Vertical motion is scored and stored with the horizontal position data. The software records these coordinates for later playback and analysis. Suitable manipulation of the recorded pattern by analysis methods can reveal subtle changes in animal behavior over the course of an experiment, between experiments, and / or between animals.

Features

Distance Travelled (cm)
Resting Time (sec) 
Stereotypic Time (sec)
Ambulatory Time (sec)
Bursts of Stereotypic Movement
Horizontal Beam Break Counts
Ambulatory Beam Break Counts
Vertical Counts
Bursts of Vertical Movement
Time in Square Analysis
Raw Data Storage (GLP compliant)
Real Time Monitoring
Validation Protocols
Staggered Start
Re-Analysis of Data
16 beams per axis
Sensors available with 1" (2.54 cm) or 0.5" (1.27cm) beam spacing.
17.5" (44.5 cm) Cage comes with base plate of 23.25" x 23.25" (59cm)
9.5" (24 cm) comes with base plate of 12.625" (32.7 cm)

 

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Hot Plate Analgesia Meter

Columbus Instruments' Hot Plate Analgesia Meter is designed for rapid and efficient screening of analgesia levels in small laboratory animals. When placed on the hot surface of the plate, animals will lift their paws and lick them (paw-lick response) due to attainment of pain threshold. The hot plate can provide a constant 55oC surface; low enough to avoid harm to subjects, yet high enough to be uncomfortable. The hot plate unit has a built-in digital thermometer with an accuracy of 0.1oC and a timer with an accuracy of 0.1 second. A remote foot-switch completely controls the test sequence for rapid hands-free screening. A standard RS-232 serial port can be connected to any personal computer to save data directly in disk files. The RS-232 output comes complete with serial cable and software for Windows compatible computers.
The animal is placed on the hot plate, confined by a clear acrylic cage which surrounds the plate. The Start/Stop button, or foot-switch is pushed to activate the timer. Time is displayed in tenths of a second until the experimenter observes temperature discomfort (paw-lick response) and pushes the Start/Stop button or foot-switch to deactivate the timer.

Features

Surface Temperature Range: 30°C to 79.9°C precisely controlled to within 0.25°C across the plate
Built-in Digital Thermometer
Built-in Digital Timer
RS-232 transfer of data
Start/Stop foot switch control
Extra thick (3/4") anodized aluminum plate provides a very stable and even temperature
Size of Heated Surface: 10" x 10" x 0.75" (254mm x 254mm x 19mm)
Temperature Range: 30° to 79.9° centigrade
Temperature Accuracy: +/- 0.1°C
Surface material: Hard Black Anodized Aluminium
Accuracy of Timer: 0.1 seconds

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Incapacitance Tester

The new Columbus Instruments Incap incapacitance meter assesses the downward force applied by each hind-limb as it relates to injury or inflammation discomfort. InCap provides two precise force transducers. The subject's hind paw pads are placed onto each of these transducers and a special animal restrainer is provided to promote the proper location of animal pads on the respective force transducers. Once the animal is in place, activation of InCap initiates a measurement cycle during which a number of force measurements are performed and averaged. The period over which these measurements are recorded is under user control; adjustable between 2 to 8 seconds. At the conclusion of the measurement, the resulting data is displayed to a resolution of 0.01 

gram-force. If connected to a PC by RS-232, InCap will transmit the numerical results and a data header containing user-defined information about the experiment and animal(s) under test.

Features

Software Included
Foot Switch to trigger "Start" of measurement
Operates in "Stand Alone" mode or via Windows compatible PC (2000 or better)
Sensor Range (mice, rats, and guinea pigs): 1 Kg per transducer. Subject max weight is 1 Kg
Resolution: 0.01 gram-force

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Tail Flick Analgesia Meter

Columbus Instruments' Tail-Flick Analgesia Meter provides an easy to use method in determining pain sensitivity accurately and reproducibly in rats and mice. The instrument has a shutter-controlled lamp as a heat source. The lamp is located below the animal to provide a less confining environment and is kept in a continuously illuminated state so that the heat source provides a constant temperature to the animal's tail, avoiding the lamp warm-up temperature variations that non-shuttered systems suffer from.

Features

Automatic or manual detection of tail-flick response
Foot-switch controlled shutter for manual operation
Front panel LED timer display is accurate to 0.1 second
Timer Resolution: 0.1 seconds
Dimension of testing area: 19" x 13" (48cm x 33cm)
Number of lamp intensity settings: 25

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Passive / Active Avoidance Box

PACS-30 is an automated system employed in the testing of avoidance behavior. Each subject is housed within a cage that has been divided by a centrally located wall. The wall has an opening that allows the subject to pass between the compartments. The lid of each compartment contains a light source. The acoustic source is on the center divider. The subject walks on a shocker grid assembly that spans the entire floor area of both compartments. A series of photocells detects the subject position within the cage.
When configured for active avoidance, PACS-30 presents a user-programmed sequence of stimuli to the subject. In response, the subject must relocate to the adjoining compartment within a preset time in order to avert the presentation of a mild shock. Controlling software coordinates stimulus presentation and behavioral responses in up to 30 avoidance cages. Latency from stimuli onset to transfer is recorded to a data file.

Features

Performs both Active and Passive Avoidance Testing
Supports operation of up to 30 boxes
Standard visual and acoustical stimuli
Cage made of Makrolon
Avoidance Cage Dimensions: 19"L x 9"W x 10.75"H (48cm x 23cm x 27cm)
Motion Detection Method: Multiple Infrared Beams
Electric Stimulus
Cage Material: Makrolon & Stainless Steel
Stimulus Voltage: 162 to 200 volts
Shock Method: True Constant-Current, 100ms pulse every 250ms (4Hz)
Shock Current: Range of 0-1000uA. 11 fixed set-points (0-10) factory selected at: (0, 100, 200, 300, 400, 500, 600, 700, 800, 900, 1000uA) automatic calibration.
Stimulus Current Regulation: 1% for 0-163 KOhms.
Audio Stimulus
Sound Frequency: Range of 200-13,000Hz in 100Hz steps with automatic calibration
Sound Volume: Range of Mute-115dB. 11 adjustable set-points (0-10) factory selected at: (Mute, 70, 75, 80, 85, 90, 95, 

100, 105, 110, 115dB) adjustable ±3dB
Light Stimulus
Lamp: Phillips Luxeon K2 LED, warm white output from 0-150Lux
Lamp Intensity: Range of 0-150Lux. 11 adjustable set-points (0-10) factory selected at: (0, 15, 30, 45, 60, 75, 90, 105, 120, 135, 150Lux) adjustable ±10Lux

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Rota Rod

Columbus Instruments' implementation of the classic rotating rod enhanced with features that assist monitoring and recording animal performance. Up to four animals may be simultaneously tested for their ability to maintain themselves upright on a rotating rod. Animals are placed on a spindle within a lane sized to the subject under test. The operator may select accelerating or constant speed mode of operation as well as a slow speed waiting mode before acceleration takes place. Speed and acceleration rate are programmable. An animal fall is detected by infrared photo-cells which cross the space just above the spindle. Once all the photocells lose sight of the animal, the time is recorded.

There are two diameters of easily interchanged rotating rods; one for mice and another for rats (see specs below for measurements).

Features

Number of Exercise Lanes: 4
Rotarod Spindle Speed Range: 0 - 99.9 RPM
Acceleration Increments: 0.1 RPM per second. to 20.0 RPM per second
Mouse Spindle Dimensions: 3.0 cm x 9.5 cm
Rat Spindle Dimensions: 7.0 cm x 9.5 cm
Fall height From Rod center: 44.5 cm
Unit Dimensions (LxWxH): 61cm X 56cm X 77cm
Weight 27.5 kg
Data Recorded: Running duration, Rotarod speed at time of fall, distance travelled
Animal Detection Method: Scanning infrared beam (32) sensors monitor animals absence from rod assembly.
Power Connections: 100 Vac to 240 Vac @ 50-60 Hz Auto configurable.
Power Consumption: 70 Watts
Fuse size: 3 amp slow blow
Communication (optional): RS-232 to RS422 (CIBUS) Multi drop. (Max of 64
devices) 

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Hole Poke Activity Meter

A special adaptation of the Opto Max Activity Monitor gives the ability to quantitatively measure exploratory behavior. The typical configuration consists of a hole poke board with nine (9) to sixteen (16) holes lying over horizontal X and Y axis sensors. Above the board are a second set of X/Y axis sensors. Data collected includes frequency and duration of each "nose poke" as well as positional and ambulatory data (distance travelled, zone entries, ambulatory vs. total movement, etc.). System comes inclusive with Windows software (Auto Track).

Features

Each sensor pair equipped with 16 IR beams, 1" (25.4 mm) apart provide high resolution for differentiation between ambulatory and non-ambulatory movements for both rats and mice.
Economical! Each single pair of sensors can monitor 1 cage with 16 IR beams or 2 smaller cages with 8 IR beams.
Ability to monitor small, as well as large, animal cages (up to 1 m x 1 m).
Sensors can be positioned side by side for creating longer sensors (32 or 48 IR beams), one above another to separately measure horizontal and vertical activity or in X-Y configuration.
"Daisy Chain" connections minimize cables and make it ideal for large multiple cage systems.
RS-232 communication with computer provides convenient interface to computer. Software computes animal activity and animal position within the cage.
Each sensor functions as both emitter and receiver. 

Each sensor is equipped with its own microcomputer for scanning IR beams and communication with computer.
Double modulation of IR beams and use of infrared filters provide high sensitivity and immunity to ambient light interference.

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Lick Counter

DM-8 monitors contact between animal and water bottle sipper tube. It is a classical implementation of electrical conductivity as a means of sensing contact. In this application, the animal stands upon a wire (stainless steel) floor in order to drink from a stainless steel sipper tube. An electrical pathway is completed that allows an imperceptible current (less than 1x10-6 ampere) to pass through the animal. Electronics within the DM-8 Control Unit sense the current flow, converting it into signals that are recorded using Columbus Instruments' Computer Counter line of interface equipment. In practice, each 'count' indicates one lick from the sipper tube. A DM-8 Control Unit supports up to eight drinking dispensers.

Features

Dispenser Volume: Approximately 150ccm
Sensing Current: less than 1 microampere 

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Volumetric Drinking Monitor

Columbus Instruments' new Precision Drinking Monitor measures liquid consumption of mice and other small animals with 20 microliters resolution. Liquid is delivered to the licking dispensers in measured 20 microliter drops by the special pump. The liquid reservoir can be placed above or below the animal cage and can be common for multiple animals. When the animal removes one drop, the next is being delivered to the dispenser by the pump. Multiple dispensers can be placed in single or different cages. The standard number of liquid dispensers is 8, but the system is capable of monitoring consumption for a few hundred animals at a time. There is no possibility of leaks, which plague other dispensers.

The Columbus Instruments Precision Drinking Monitor is far superior over other common "lick counters" on the market. Information is presented volumetrically in microliters of liquid consumed rather than simply a number of licks on the sipper tube with varying amount of liquid consumed. Nevertheless, the Precision Drinking Monitor can be equipped with circuitry, which will count licks, if such an arrangement is valuable to the researcher. Windows software allows integrating the Precision Drinking Monitor with other parameters such as Oxygen Consumption, Food Consumption, Animal Activity, Urine Collection, etc., making this a unique and valuable instrument in lab animal mutagenesis

Features

20 Micro-liter resolution
Uses a common liquid reservoir
Patented [US # 6,463,879] micro pump technology
MDI Software compatible 

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